The 4216 is a low end 16 Core CPU. With HT enabled it reports 32 logical CPU to your Hypervisor. So you ratio is > 1:1 if you leave HT out of the game. In larger farms HT add up to 25% so there is a benefit. But as often always... it depends on YOUR workload.
About the CPU configuration it doesnt make a difference as long as you stay within your NUMA Node size. I personally would avoid the 3 socket configuration it doesnt feel right. I remember in the early days of AMD 3 Core CPUs that not all OS CPU schedulers like them.
Why not just edit the CPU config and watch esxtop when performing some workload?
Regards,
Joerg