Then your issue is when you restore, if you take a complete backup of the server using whatever tool, the problem will be when restoring the server in case of disaster.
You will loose some of the configuration, statistics, etc..
I'd rather you take backup for the DB only, and build a new server in case of disaster and point it to the restored DB instead of taking a full vCenter backup (to save storage space).
The best scenario is to put your DB on a different server.