If you are expanding hard disk and RAM capacity of the ESX host, it won't have any adverse impact on the VMs. Only thing to consider here is the downtime for the VMs while the host is undergoing maintenance/upgrade.
So the safest way to go about it, is to shut down the existing VMs, power off the host and then perform the upgrade. Once upgrade is done power on host and ensure all is well, then the existing VMs can be powered on, followed by creation of the new VM which is to utilize the additional capacities.