I do this in my shop.
You can run two vDR appliances with no problem.
Each appliance will run a maximum of eight backup jobs at the same time.
You can have them scheduled for the same time. Your only limitation may
be the available bandwidth to your backup device, or if writing to a slow
device, the ability to write the data at the destination.
You must not try to backup the same Virtual Machine on more than
one vDR appliance.