Hello @Futures Support,
Splitting the servers from different groups into different clusters instead should work, but it implies an extra burden related to management and deployment on your side, that's why I didn't even suggested that option. Also, there's no way of configuring a gateway-sender to connect to a specific gateway-receiver.
The documentation here [1] states that the same regions should be configured both in the source and target clusters in order for the distribution to work properly, but it doesn't say anything about supporting or not the usage of server groups.
As a said before, this would be a nice feature to have in the product, so I'd suggest to open a Support Ticket and ask for the steps to create a Feature Request.
Best regards.
[1]:https://gemfire.docs.pivotal.io/910/geode/topologies_and_comm/multi_site_configuration/setting_up_a_multisite_system.html