Brian, thanks for referencing my post in this.
John, I'll follow-up with a bit more information below on what we've seen so far. I've also passed this post over to our SE so that they have an additional set of cases to reference.
Systems impacted: both Windows 7 and Windows 10
Patch versions: some with May patches, some with June
SEP Versions: Definitely 14.0.3929.1200 and 14.0.3897.1101, haven't dug into others yet but it appears to be version-agnostic
SEP IPS Definitions: Still haven't established a pattern here on our end. I'll take your word on those definitions.
Date of first occurrence: June 7 @ 7:08 AM
We've also found that in some cases, disabling that one signature hasn't been enough - users still experience general slowness with Office apps opening, or software not launching. We tested disabling MEM entirely, which seemed to resolve this, but there is the major drawback of losing all of those protections which are still working. Hopefully this helps, and feel free to shoot me a direct message if you want to discuss environment specifics. We've noticed one common piece of software among impacted machines.
Hopefully this issue gets sorted out soon for both our sakes.