I activated logging for the LDAP signing part as explained by MS in 2 environments running ITMS, in both environments we have events 2889 about LDAP binding without requesting signing, but none are related to ITMS, so looks like it won't cause any issues.
In 1 environment I will be able to force it manually in the next 2 weeks as I have only 1 source to fix, will post results regarding ITMS once I"m able to (if not somebody else replies earlier ;))