Use Locations. You can create each room as a Location and have a hierarchy of Locations. So Rooms 1-5 can be in a Location called Building A.
If each room had its own subnet there is a Task to assign computers to Locations by subnet, otherwise you'll just have to keep track manually of which computer is in which room. See:
"Creating a location"
http://www.symantec.com/docs/HOWTO93942