asafy
If you're wanting to monitor .NET Web API, it requires .NET FW 4.5 so please check our Compatibility Guide for details on which versions support the framework.
If you're using ASP.NET MVC, we have a supported FieldPack which will instrument the frontend, models, views, and controllers. If you're interested in seeing that, please contact your CA Pre-sales or Services contact.
-Hiko