Hello Walter,
I don't see any expected error here, I assumed the agent was not connecting to the Enterprise Manager over HTTPS, but perhaps you mean that it still connects but causes a problem with the application that is monitored.
If it is an application issue, you could try commenting out this option in webservices.pbd.
TurnOn: WCFRuntimeTracing
That is just based on common occurrence, and also only relevant if the application uses WCF.
I think this is the sort of thing that needs more investigation through support cases, to provide all of the logs you have and any details about the application, what version of IIS is being used, particular technologies like WCF, MVC being used
Thanks,
David